The existence of ample amounts of hydrogen in the subsurface ocean of Enceladus indicates that microbes--if any exist there--could use it to obtain energy by mixing with carbon dioxide dissolved in water. This particular chemical reaction, termed methanogenesis, because it manufactures methane as a byproduct, may have been of critical importance in the emergence of life on our planet.
Makemake is a classical KBO. This means that its orbit is situated far enough away from Neptune to remain in a stable stage over the entire age of our more than 4 billion year old Solar System. Classical KBOs have perihelia that carry them far from the Sun, and they are also peacefully free from Neptune's perturbing influence. Such objects show relatively low eccentricities and circle our Star in a way that is similar to that of the major planets. However, Makemake is a member of what is referred to as a "dynamically hot" class of classical KBOs, which instead display a high inclination when compared to other classical KBOs.