Makemake is about a fifth as bright as Pluto. However, despite its comparative brightness, it was not discovered until well after a number of much fainter KBOs had been detected. Most of the scientific hunts for minor planets are conducted relatively close to the region of the sky that the Sun, Earth's Moon, and planets appear to lie in (the ecliptic). This is because there is a much greater likelihood of discovering objects there. Makemake is thought to have evaded detection during earlier searches because of its relatively high orbital inclination, as well as the fact that it was at its greatest distance from the ecliptic at the time of its discovery--in the northern constellation of Coma Berenices.
"Cassini's seven-plus years... have shown us how beautifully dynamic and unexpected the Saturn system is," commented project scientist Dr. Linda Spilker of NASA's JPL to Time Magazine's online edition on March 23, 2012.
"From what we know about cloud formation on Titan, we can say that such methane clouds in this area and in this time of year are not physically possible. The convective methane clouds that can develop in this area and during this period of time would contain huge droplets and must be at a very high altitude--much higher than the 6 miles that modeling tells us the new features are located," Dr. Rodriguez explained in the September 24, 2018 JPL Press Release.