The existence of ample amounts of hydrogen in the subsurface ocean of Enceladus indicates that microbes--if any exist there--could use it to obtain energy by mixing with carbon dioxide dissolved in water. This particular chemical reaction, termed methanogenesis, because it manufactures methane as a byproduct, may have been of critical importance in the emergence of life on our planet.
Makemake is about a fifth as bright as Pluto. However, despite its comparative brightness, it was not discovered until well after a number of much fainter KBOs had been detected. Most of the scientific hunts for minor planets are conducted relatively close to the region of the sky that the Sun, Earth's Moon, and planets appear to lie in (the ecliptic). This is because there is a much greater likelihood of discovering objects there. Makemake is thought to have evaded detection during earlier searches because of its relatively high orbital inclination, as well as the fact that it was at its greatest distance from the ecliptic at the time of its discovery--in the northern constellation of Coma Berenices.
Dr. Porco believes that the icy moon, with its underground liquid sea of water, organics, as well as an energy source, may potentially host life similar to that found in analogous environments on Earth. The March 2012 images of Cassini's "tiger stripes" revealed that these cracks widen and narrow, as was suspected from pictures taken previously. The fissures also change over time more frequently than was originally thought. The two opposite sides of the fissures move laterally relative to one another. This is analogous to the way two banks of the San Andreas Fault can move forward and back, as well as in opposite directions. The greatest slipping and sliding happens when Enceladus is closest to Saturn--as scientists expected.